Literature summary extracted from

Miikkulainen, P.; Hoegel, H.; Rantanen, K.; Suomi, T.; Kouvonen, P.; Elo, L.L.; Jaakkola, P.M.
HIF prolyl hydroxylase PHD3 regulates translational machinery and glucose metabolism in clear cell renal cell carcinoma (2017), Cancer Metab., 5, 5-5 .

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.14.11.29	hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2	Homo sapiens	-	hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.11.29	Homo sapiens	Q9H6Z9	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.14.11.29	786-O cell	-	Homo sapiens	-
1.14.11.29	clear cell renal cell carcinoma cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.11.29	hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2	-	Homo sapiens	hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.14.11.29	HIF prolyl hydroxylase	-	Homo sapiens
1.14.11.29	PHD3	-	Homo sapiens

General Information

EC Number	General Information	Comment	Organism
1.14.11.29	malfunction	isoform PHD3 silencing leads to downregulation of most glycolytic enzymes from glucose transport to lactate production supported by the reduction in extracellular acidification and lactate production and increase in cellular oxygen consumption rate	Homo sapiens
1.14.11.29	physiological function	isoform PHD3 is involved in the maintenance of key cellular functions including glycolysis and protein synthesis in clear cell renal cell carcinoma. The enzyme regulates ribosomal subunits and protein translation in clear cell renal cell carcinoma	Homo sapiens

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Release 2023.1 (January 2023)